This book constitutes the refereed proceedings of the 6th IFIP WG 6.1 International Conference on Distributed Applications and Interoperable Systems, DAIS 2006, held in Bologna, Italy, June 2006. The book presents 21 revised regular and 5 revised work-in-progress papers, on architectures, models, technologies and platforms for interoperable, scalable and adaptable systems and cover subjects as methodological aspects, tools and language of building adaptable distributed and interoperable services, and many more.